The effects of 24-week intake of hydrogen water with high H2 concentration on body structure, blood lipid profiles, and biomarkers of inflammation in men and women with metabolic syndrome: A randomized controlled trial. Published March 24, 2020.
We have put a link to the full official medical report at the end of the article.
Medical persons and research scholars: Tyler W Lebaron , Ram B Singh, Ghizal Fatima, Kumar Karthiki, Jagdish P Sharma, Serj M Ostojic, Anna Gvozdyakova, Branislav Kura, Mami Noda, William Mototo, Mohammad Arif Niyaz, Jan. Slezek.
Institutes involved in the study:
1.Centre for Experimental Medicine, Institute of Cardiac Research, Slovak Academy of Sciences, Bratislava, Slovak Republic;
2.Molecular Hydrogen Institute, Enoch, UT, USA;
3.Hospital and Research Institute, Moradabad, India;
4.Era Medical College, Lucknow, India;
5.Laboratory of Applied Bioenergetics, Faculty of Sports and Vocational Education, University of Novi Sad, Serbia;
6.Faculty of Health Sciences, University of Pécs, Pécs, Hungary;
7.Faculty of Medicine, Pharmacobiochemical Laboratory of the 3rd Medical Department, Comenius University of Bratislava, Bratislava, Slovakia;
8.Laboratory of Pathophysiology, Graduate School of Pharmaceutical Science, Kyushu University, Fukuoka, Japan;
9.Third Internal Medicine Clinic, Faculty of Medicine, Comenius University, Bratislava, Slovakia;
10.Centre of Nutrition Research, International College of Nutrition, Moradabad, India
OBJECTIVE OF STUDY: Metabolic syndrome is associated with several medical risk factors including dyslipidemia, hyperglycemia, and obesity, which has become a global pandemic. The consequences of this condition increase the risk of cardiovascular and neurological disease, and increased mortality. Its pathophysiology is associated with redox dysregulation, excessive inflammation, and disturbances in cellular homeostasis. Molecular hydrogen (H2) reduces oxidative stress, improves cell function, and reduces chronic inflammation. Preclinical and clinical studies have shown impressive effects of hydrogen water on specific features of metabolic syndrome, but the outcome of long-term hydrogen water intake by people in this condition remains poorly understood by much of the public.
METHODS: We conducted a randomized, double-blind, placebo-controlled trial in 60 patients (30 men and 30 women) with metabolic syndrome. An initial observation period of one week was used to obtain baseline clinical data. This was followed by randomized administration of either placebo or high concentration hydrogen water (>5.5 millimoles H2 per day) for 24 weeks.
RESULTS: The group drinking highly saturated hydrogen water significantly reduced blood cholesterol and glucose levels, attenuated serum hemoglobin A1c, and improved biomarkers of inflammation. Homeostasis was found to be redox compared with the placebo group drinking plain water (P<0.05). In addition, the action of H2 showed a tendency to decrease body mass index and waist-to-hip ratio.
CONCLUSION: Our results confirm that hydrogen water with high H2 concentration has positive effects as a therapeutic method to reduce risk factors and improve health status in people with metabolic syndrome.
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